9.B.23.1.1
TMEM106B (transmembrane protein 106B) plays an integral role in microglia and oligodendrocyte function (Lok and Kwok 2021). It is of 274 aas with 1 or 2 TMSs. It is involved in several diseases and is linked to cell death (see family description) (Nicholson and Rademakers 2016). It exerts its effects on FTLD-TDP disease risk through alterations in lysosomal pathways, and TMEM106B and C9orf72 may interact in FTLD-TDP pathophysiology (Busch et al. 2016). Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation (Bauer et al. 2022). The TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia (Marks et al. 2024).
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| Accession Number: | Q9NUM4 |
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| Protein Name: | Transmembrane protein 106B |
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| Length: | 274 |
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| Molecular Weight: | 31127.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Late endosome membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MGKSLSHLPL HSSKEDAYDG VTSENMRNGL VNSEVHNEDG RNGDVSQFPY VEFTGRDSVT
61: CPTCQGTGRI PRGQENQLVA LIPYSDQRLR PRRTKLYVMA SVFVCLLLSG LAVFFLFPRS
121: IDVKYIGVKS AYVSYDVQKR TIYLNITNTL NITNNNYYSV EVENITAQVQ FSKTVIGKAR
181: LNNITIIGPL DMKQIDYTVP TVIAEEMSYM YDFCTLISIK VHNIVLMMQV TVTTTYFGHS
241: EQISQERYQY VDCGRNTTYQ LGQSEYLNVL QPQQ