9.B.23.1.4
TMEM106C of 250 aas and 2 TMSs. TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma (HCC) (Duan et al. 2021). TMEM106C is overexpressed in HCC, and its inhibition suppresses the proliferation and metastasis of HCC. Upregulation of TMEM106C correlated with sex, tumor stage, tumor grade and prognosis. Overexpression of TMEM106C was linked to functional networks involving organelle fission and cell cycle signaling pathways (Duan et al. 2021).
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| Accession Number: | Q9BVX2 |
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| Protein Name: | Transmembrane protein 106C |
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| Length: | 250 |
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| Molecular Weight: | 27875.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT CLTCQGTGYI
61: PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG LVVFFLFPHS VLVDDDGIKV
121: VKVTFNKQDS LVILTIMATL KIRNSNFYTV AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR
181: SEQLVNFTGK AEMGGPFSYV YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY
241: VDCGGNSTAI