9.B.27.1.10
Stasimon or TMEM41b of 320 aas and (5 or) 6 TMSs in a probable 1 + 2 + 2 + 1 TMS arrangement. The protein localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development (Van Alstyne et al. 2018). It is a lipid scramblase involved in the processing and transport of GPI-anchored proteins (Cao et al. 2023). Inhibition of TMEM41B-dependent lipid scrambling promotes GPI-AP processing in the ER through PGAP1 stabilization, slowing protein trafficking (Cao et al. 2023).
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| Accession Number: | Q9VX39 |
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| Protein Name: | Transmembrane protein 41 homolog |
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| Length: | 320 |
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| Molecular Weight: | 35833.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSYCSGVAIS ADEGITMRNG RAKALQEHSP DQVATPLLPQ VPPQEQQDLN PQQQQQQQQQ
61: QQATPQKQAM SADEKKATKK SLVIVAGIFV ASLVTMCYVY AIFPELNASE KQHLKIPRDI
121: QDAKMLAKVL DRYKDMYYFE VMFGVVVAYV FLQTFAIPGS LFLSILLGFL YKFPIALFLI
181: CFCSALGATL CYTLSNLVGR RLIRHFWPKK TSEWSKHVEE YRDSLFNYML FLRMTPILPN
241: WFINLASPVI GVPLHIFALG TFCGVAPPSV IAIQAGKTLQ KMTSSSEAFS WTSMGILMAC
301: ACASLLPGLL KNKFKHKKEA