TCDB is operated by the Saier Lab Bioinformatics Group

9.B.34 The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family

The KPSH family, is a heterogeneous group of multidomain proteins, each exhibiting a different set of domain combinations, suggesting differing catalytic and regulatory functions. Catalytic domains in these proteins include kinases, phosphatases, cyclic di-GMP synthetases and cyclic di-GMP hydrolases (KPSH). None of the members of the KPSH family have been functionally characterized, but the sequence similarity with characterized proteins and protein domains allowed functional predictions with a high degree of confidence (Mansour et al., 2007). The N-terminal 'transporter' domain has not been shown to have transport activity.

This family belongs to the: BART Superfamily.

References associated with 9.B.34 family:

Hu, L., C.J. Grim, A.A. Franco, K.G. Jarvis, V. Sathyamoorthy, M.H. Kothary, B.A. McCardell, and B.D. Tall. (2015). Analysis of the cellulose synthase operon genes, bcsA, bcsB, and bcsC in Cronobacter species: Prevalence among species and their roles in biofilm formation and cell-cell aggregation. Food Microbiol 52: 97-105. 26338122
Imai, T., S.J. Sun, Y. Horikawa, M. Wada, and J. Sugiyama. (2014). Functional reconstitution of cellulose synthase in Escherichia coli. Biomacromolecules 15: 4206-4213. 25285473
Mansour, N.M., M. Sawhney, D.G. Tamang, C. Vogl, and M.H. Saier, Jr. (2007). The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 274: 612-629. 17288550
Omadjela, O., A. Narahari, J. Strumillo, H. Mélida, O. Mazur, V. Bulone, and J. Zimmer. (2013). BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. Proc. Natl. Acad. Sci. USA 110: 17856-17861. 24127606
Römling, U. and M.Y. Galperin. (2015). Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions. Trends Microbiol. 23: 545-557. 26077867
Zogaj, X., M. Nimtz, M. Rohde, W. Bokranz, and U. Römling. (2001). The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix. Mol. Microbiol. 39: 1452-1463. 11260463