9.B.367.1.4
Erythrocyte-binding antigen 175, EBA-175, of 1435 aas and possibly two TMSs, N- and C-terminal. It may bind to human erythrocytes via glycophorin A (TC# 8.A.168.1.1) (Jaskiewicz et al. 2019). Binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. EBA-175 may act as bridge between erythrocytes and merozoites (Camus and Hadley 1985).
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| Accession Number: | P19214 |
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| Protein Name: | Erythrocyte-binding antigen 175 |
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| Length: | 1435 |
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| Molecular Weight: | 167390.00 |
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| Species: | Plasmodium falciparum (isolate Camp / Malaysia) [5835] |
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| Substrate |
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1: MKCNISIYFF ASFFVLYFAK ARNEYDIKEN EKFLDVYKEK FNELDKKKYG NVQKTDKKIF
61: TFIENKLDIL NNSKFNKRWK SYGTPDNIDK NMSLINKHNN EEMFNNNYQS FLSTSSLIKQ
121: NKYVPINAVR VSRILSFLDS RINNGRNTSS NNEVLSNCRE KRKGMKWDCK KKNDRSNYVC
181: IPDRRIQLCI VNLSIIKTYT KETMKDHFIE ASKKESQLLL KKNDNKYNSK FCNDLKNSFL
241: DYGHLAMGND MDFGGYSTKA ENKIQEVFKG AHGEISEHKI KNFRKEWWNE FREKLWEAML
301: SEHKNNINNC KNIPQEELQI TQWIKEWHGE FLLERDNRSK LPKSKCKNNT LYEACEKECI
361: DPCMKYRDWI IRSKFEWHTL SKEYETQKVP KENAENYLIK ISENKNDAKV SLLLNNCDAE
421: YSKYCDCKHT TTLVKSVLNG NDNTIKEKRE HIDLDDFSKF GCDKNSVDTN TKVWECKNPY
481: ILSTKDVCVP PRRQELCLGN IDRIYDKNLL MIKEHILAIA IYESRILKRK YKNKDDKEVC
541: KIINKTFADI RDIIGGTDYW NDLSNRKLVG KINTNSKYVH RNKKNDKLFR DEWWKVIKKD
601: VWNVISWVFK DKTVCKEDDI ENIPQFFRWF SEWGDDYCQD KTKMIETLKV ECKEKPCEDD
661: NCKSKCNSYK EWISKKKEEY NKQAKQYQEY QKGNNYKMYS EFKSIKPEVY LKKYSEKCSN
721: LNFEDEFKEE LHSDYKNKCT MCPEVKDVPI SIIRNNEQTS QEAVPEENTE IAHRTETPSI
781: SEGPKGNEQK ERDDDSLSKI SVSPENSRPE TDAKDTSNLL KLKGDVDISM PKAVIGSSPN
841: DNINVTEQGD NISGVNSKPL SDDVRPDKKE LEDQNSDESE ETVVNHISKS PSINNGDDSG
901: SGSATVSESS SSNTGLSIDD DRNGDTFVRT QDTANTEDVI RKENADKDED EKGADEERHS
961: TSESLSSPEE KMLTDNEGGN SLNHEEVKEH TSNSDNVQQS GGIVNMNVEK ELKDTLENPS
1021: SSLDEGKAHE ELSEPNLSSD QDMSNTPGPL DNTSEETTER ISNNEYKVNE REDERTLTKE
1081: YEDIVLKSHM NRESDDGELY DENSDLSTVN DESEDAEAKM KGNDTSEMSH NSSQHIESDQ
1141: QKNDMKTVGD LGTTHVQNEI SVPVTGEIDE KLRESKESKI HKAEEERLSH TDIHKINPED
1201: RNSNTLHLKD IRNEENERHL TNQNINISQE RDLQKHGFHT MNNLHGDGVS ERSQINHSHH
1261: GNRQDRGGNS GNVLNMRSNN NNFNNIPSRY NLYDKKLDLD LYENRNDSTT KELIKKLAEI
1321: NKCENEISVK YCDHMIHEEI PLKTCTKEKT RNLCCAVSDY CMSYFTYDSE EYYNCTKREF
1381: DDPSYTCFRK EAFSSMIFKF LITNKIYYYF YTYKTAKVTI KKINFSLIFF FFFSF