9.B.39.1.6
Sensory neuron membrane protein 1, SNMP1 of 551 aas and 2 TMSs (N- and C-terminal). Plays an olfactory role that is not
restricted to pheromone sensitivity. Has a role in detection and signal
transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl
acetate (cVA). Not required for sensitivity to general odorants. Acts in
concert with Or67d and lush to capture cVA molecules on the surface of
Or67d expressing olfactory dendrites and facilitate their transfer to
the odorant-receptor Orco complex. Essential for the
electrophysiological responses of these olfactory sensory neurons (Benton et al. 2007; Jin et al. 2008; Gomez-Diaz et al. 2016).
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| Accession Number: | Q9VDD3 |
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| Protein Name: | Sensory neuron membrane protein 1 |
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| Length: | 551 |
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| Molecular Weight: | 62117.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MQVPRVKLLM GSGAMFVFAI IYGWVIFPKI LKFMISKQVT LKPGSDVREL WSNTPFPLHF
61: YIYVFNVTNP DEVSEGAKPR LQEVGPFVFD EWKDKYDLED DVVEDTVSFT MRNTFIFNPK
121: ESLPLTGEEE IILPHPIMLP GGISVQREKA AMMELVSKGL SIVFPDAKAF LKAKFMDLFF
181: RGINVDCSSE EFSAKALCTV FYTGEIKQAK QVNQTHFLFS FMGQANHSDS GRFTVCRGVK
241: NNKKLGKVVK FADEPEQDIW PDGECNTFVG TDSTVFAPGL KKEDGLWAFT PDLCRSLGAY
301: YQHKSSYHGM PSMRYTLDLG DIRADEKLHC FCEDPEDLDT CPPKGTMNLA ACVGGPLMAS
361: MPHFYLGDPK LVADVDGLNP NEKDHAVYID FELMSGTPFQ AAKRLQFNLD MEPVEGIEPM
421: KNLPKLILPM FWVEEGVQLN KTYTNLVKYT LFLGLKINSV LRWSLITFSL VGLMFSAYLF
481: YHKSDSLDIN SILKDNNKVD DVASTKEPLP SANPKQSSTV HPVQLPNTLI PGTNPATNPA
541: THHKMEHRER Y