9.B.39.1.8
Debris buster, Dsb of 615 aas and 2 TMSs, one near the N-terminus, and one near the C-terminus. Drosophila has 14 SR-B members whose functions are not well known. It is one of the scavenger receptors class B (SR-B) which are multifunctional transmembrane proteins which in vertebrates participate in lipid transport, pathogen clearance, lysosomal delivery and intracellular sorting. Dsb sorts components of the apical extracellular matrix which are essential for airway physiology. Since SR-B LIMP2-deficient mice show reduced expression of several apical plasma membrane proteins, sorting of proteins to the apical membrane is likely an evolutionarily conserved function of Dsb and LIMP2 (Wingen et al. 2017).
|
| Accession Number: | A8JNI3 |
|---|
| Protein Name: | Debris buster, isoform D |
|---|
| Length: | 615 |
|---|
| Molecular Weight: | 69977.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 2 |
|---|
| Substrate |
|
|---|
1: MGLEKHYLRY GRTARDHLLD WATCGRGRRQ QQQQQQQQTH AQPSQGSTAT GRRSRPHVTH
61: RGTPLSMLIS NGVRISNNRL AVIIIGIITL ILGIILSSMP WLDYFILKNL RLWNDTLSYH
121: YWQRPGVIRL TKLYIYNVTN PDGFLRGEKP HLQEVGPFVY REDMQKVNVK FHENNYTVSY
181: QHKKILQFVP ELSIDKDTPI TTPNIPLLTL TSLSPKLGYL LSKTISVVVT AAQFKPFINV
241: TAEQLAFGYD DALVSLAHRF YPKHMRPMER MGLLLGRNGT LTEVSSVKTG MDSMDQFGYI
301: DQLNGLDHLP HWSEPPCTSI AGSEGSFFPP RELTKSEVVH IYDKDLCRII PLKYVESLEK
361: DGIAADLFRL PNNSYGDSAH NPENKCYDTS EYEPIQGLQN ISPCQYGAPV YISNPHFFES
421: HPDLLNSVEG LKPEREKHET YFKIQPKLGV PLEGKVRIQL NLKVTRAKDV YPVRDFRDFV
481: FPVMWLEEGI SELTPAIKRW IYLGTVIAPS AVPIGSYLMI LGGAFAIIFS FVRAYQNFMF
541: AQDPTLEILE MGRRSLRRGS SFIAHQQHRL LVHHRDSYSL LRHGPMATCL GEGNREEDAQ
601: PIIDVSLSGG ISQES