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9.B.41.1.1
Occludin (with residues 70-220 comprising a MARVEL domain, and residues 430-520 comprising an Occludin_ELL domain.

Accession Number:Q16625
Protein Name:Occludin
Length:522
Molecular Weight:59144.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

DIP: DIP-42791N
Entrez Gene ID: 100506658   
Pfam: PF01284    PF07303   
KEGG: hsa:100506658   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005923 C:tight junction
GO:0005515 F:protein binding
GO:0005198 F:structural molecule activity
GO:0006921 P:cellular component disassembly involved in apoptosis
GO:0006461 P:protein complex assembly

References (10)

[1] “Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.”  Ando-Akatsuka Y.et.al.   8601611
[2] “Occludin confers adhesiveness when expressed in fibroblasts.”  Van Itallie C.M.et.al.   9175707
[3] “Human protein factory for converting the transcriptome into an in vitro-expressed proteome.”  Goshima N.et.al.   19054851
[4] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.”  Matsuoka S.et.al.   17525332
[7] “Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.”  Han G.et.al.   18318008
[8] “Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.”  Elias B.C.et.al.   19017651
[9] “Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.”  Sallee J.L.et.al.   19332538
[10] “Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria.”  O'Driscoll M.C.et.al.   20727516
Structure:
1WPA   1XAW   3G7C     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS 
61:	PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY 
121:	GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA 
181:	ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD 
241:	PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN 
301:	VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV 
361:	DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY 
421:	PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE 
481:	YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT