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Accession Number: | Q16625 |
Protein Name: | Occludin |
Length: | 522 |
Molecular Weight: | 59144.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
DIP: | DIP-42791N |
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Entrez Gene ID: | 100506658 |
Pfam: | PF01284 PF07303 |
KEGG: | hsa:100506658 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005923
C:tight junction
GO:0005515
F:protein binding
GO:0005198
F:structural molecule activity
GO:0006921
P:cellular component disassembly involved in apoptosis
GO:0006461
P:protein complex assembly
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References (10)[1] “Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.” Ando-Akatsuka Y.et.al. 8601611 [2] “Occludin confers adhesiveness when expressed in fibroblasts.” Van Itallie C.M.et.al. 9175707 [3] “Human protein factory for converting the transcriptome into an in vitro-expressed proteome.” Goshima N.et.al. 19054851 [4] “The DNA sequence and comparative analysis of human chromosome 5.” Schmutz J.et.al. 15372022 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [7] “Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.” Han G.et.al. 18318008 [8] “Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions.” Elias B.C.et.al. 19017651 [9] “Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.” Sallee J.L.et.al. 19332538 [10] “Recessive mutations in the gene encoding the tight junction protein occludin cause band-like calcification with simplified gyration and polymicrogyria.” O'Driscoll M.C.et.al. 20727516
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Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS 61: PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY 121: GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA 181: ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD 241: PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN 301: VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV 361: DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY 421: PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE 481: YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT