9.B.41.2.1
MARVEL domain-containing protein 2, tricellulin, of 558 aas and 4 TMSs. Plays a role in the formation of tight junctions in
epithelial barriers. The separation of the endolymphatic and
perilymphatic spaces of the organ of Corti from one another by
epithelial barriers is required for normal hearing (Riazuddin et al. 2006). Tricellulin forms tight junctions and is a junctional redox regulator (Cording et al. 2015).
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| Accession Number: | Q8N4S9 |
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| Protein Name: | MARVEL domain-containing protein 2 |
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| Length: | 558 |
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| Molecular Weight: | 64168.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSNDGRSRNR DRRYDEVPSD LPYQDTTIRT HPTLHDSERA VSADPLPPPP LPLQPPFGPD
61: FYSSDTEEPA IAPDLKPVRR FVPDSWKNFF RGKKKDPEWD KPVSDIRYIS DGVECSPPAS
121: PARPNHRSPL NSCKDPYGGS EGTFSSRKEA DAVFPRDPYG SLDRHTQTVR TYSEKVEEYN
181: LRYSYMKSWA GLLRILGVVE LLLGAGVFAC VTAYIHKDSE WYNLFGYSQP YGMGGVGGLG
241: SMYGGYYYTG PKTPFVLVVA GLAWITTIII LVLGMSMYYR TILLDSNWWP LTEFGINVAL
301: FILYMAAAIV YVNDTNRGGL CYYPLFNTPV NAVFCRVEGG QIAAMIFLFV TMIVYLISAL
361: VCLKLWRHEA ARRHREYMEQ QEINEPSLSS KRKMCEMATS GDRQRDSEVN FKELRTAKMK
421: PELLSGHIPP GHIPKPIVMP DYVAKYPVIQ TDDERERYKA VFQDQFSEYK ELSAEVQAVL
481: RKFDELDAVM SRLPHHSESR QEHERISRIH EEFKKKKNDP TFLEKKERCD YLKNKLSHIK
541: QRIQEYDKVM NWDVQGYS