TCDB is operated by the Saier Lab Bioinformatics Group

9.B.422.  The Transmembrane Protein-26 (TMEM26) Family

Members of this family play roles in beige adipocyte formation in overweight animals (Rachid et al. 2018), and may target obesity by influencing fat oxidation and thermogenesis (Liu et al. 2019). Its gene expression is influenced by emodin (Cheng et al. 2021). Members of this family include regions that show some sequence similarity with members of TC families 1.A.82 and 9.B.440.

References associated with 9.B.422 family:

Cheng, L., S. Zhang, F. Shang, Y. Ning, Z. Huang, R. He, J. Sun, and S. Dong. (2021). Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. Front Endocrinol (Lausanne) 12: 618037. 34040579
Ishii, Y., O. Muta, T. Teshima, N. Hirasima, M. Odaka, T. Fushimi, Y. Fujii, and N. Osakabe. (2021). Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation. Nutrients 13:. 34959764
Liu, J., Y. Wang, and L. Lin. (2019). Small molecules for fat combustion: targeting obesity. Acta Pharm Sin B 9: 220-236. 30976490
Rachid, T.L., F.M. Silva-Veiga, F. Graus-Nunes, I. Bringhenti, C.A. Mandarim-de-Lacerda, and V. Souza-Mello. (2018). Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice. PLoS One 13: e0191365. 29351550
Wang, D., P.K. Korhonen, R.B. Gasser, and N.D. Young. (2018). Improved genomic resources and new bioinformatic workflow for the carcinogenic parasite Clonorchis sinensis: Biotechnological implications. Biotechnol Adv 36: 894-904. 29454982