9.B.423.1.3
L-dopachrome tautomerase, TYRP2 or DCT, of 519 aas and 2 TMSs, one a signal sequence at the N-terminus, and one a stronly hydrophobic TMS at the C-terminus. In a complex with tyrosinase (TC# 9.B.423.1.1) and TYRP1 (TC# 9.B.423.1.2), the three C-terminal TMSs may form a transmembrane bundle, possibly even a channel (Lavinda et al. 2021). It catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). This protein is involved in the melanin biosynthetic pathway.
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| Accession Number: | P40126 |
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| Protein Name: | L-dopachrome tautomerase |
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| Length: | 519 |
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| Molecular Weight: | 59145.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Melanosome membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ
61: CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER
121: KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS
181: VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF
241: ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN
301: GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT
361: LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVLHSFTD AIFDEWMKRF NPPADAWPQE
421: LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ LGYSYAIDLP VSVEETPGWP TTLLVVMGTL
481: VALVGLFVLL AFLQYRRLRK GYTPLMETHL SSKRYTEEA