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9.B.64.1.2
The Start1 protein (putative cholesterol transporter)

Accession Number:Q9W145
Protein Name:Start1
Length:583
Molecular Weight:65823.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Late endosome membrane1 / Multi-pass membrane protein2
Substrate cholesterol

Cross database links:

RefSeq: NP_611936.2   
Entrez Gene ID: 37927   
Pfam: PF10457    PF01852   
KEGG: dme:Dmel_CG3522   

Gene Ontology

GO:0015485 F:cholesterol binding
GO:0017127 F:cholesterol transporter activity
GO:0005515 F:protein binding
GO:0006694 P:steroid biosynthetic process

References (3)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis.”  Roth G.E.et.al.   14745013

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSNMDPSDVR STAQLILANA RQGNSAYNMQ YDMSRAHSIN LITEDFLAGY MQDGRMSVVR 
61:	RFFCLFVTFD LVFVSLLWLI CIVINGDNIF TAFHKQIVEY TIYKSLFDVV AVAICRFLVL 
121:	IFFYAILYIN HWSIIALSTS GSCLFLISKV FVFDWLDSKQ QVFEVILIIT SFILAWGEAW 
181:	FLDCRVIPQE RHAQHYFRTM TSNDRTPMEQ PAILIEQERP PQSVTDFYSL MDTARHSDEE 
241:	DELDDEYTQM GLDCLRKAYE IIESSDWKVE KVNQKGDTIH STQRDKIGKI YKLTARIKYP 
301:	AKALMEDLFY RIEDCPKWNP ALLESKIVRK INSYTDITYQ VSVGGGGGMV KSRDFVNLRS 
361:	CRLFYNGQIC DDDETAQLSS DDGNSSLNRS CEGSVSTISD GDSNTPLLPS SVSSCKATFP 
421:	TSSKGAAMPF DTLGNSLGAK SLGPIVNFDE EPPPLDQDEF EDAKDKVDGE ANNMTKPNVP 
481:	SVGKTKDRVW VTSAVSVQYA AVPPSPKYTR GQNIVSGFAF REIVGKSDSC IVEWVLCLDL 
541:	KGYIPRYVLD AALTSSMTDY ISNLRKHVNE LRQKGRGRAP RTH