9.B.97.2.3
Acyl transferase of 822 aas and 14 putative TMSs. Has an N-terminal TMS followed bya hydrophilic domain of about 270 aas which may include TMSs, followed by about 13 TMSs. Plays
a role in the uptake of a range of molecules including lipids and
xenobiotic compounds from the intestine to surrounding tissues. Mediates
transport of lipids from the intestine to the reproductive tract. Required
for efficient yolk transport into oocytes. Vital for embryonic
development (Brejning et al. 2014). Mutants in the nrf-6 gene have extended lifespans and increased stress
resistance (Brejning et al. 2014).
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| Accession Number: | Q09225 |
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| Protein Name: | Nose resistant to fluoxetine protein 6 |
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| Length: | 822 |
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| Molecular Weight: | 94206.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lipid |
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1: MGNMRRLLIF AVLVILTVIS NSKSSYKYDG SLFSSKELDY DETDTKAMGS VFSRYMSDSD
61: AQLILDLDFF RHFFNYAEAY RDGAEEGNLE LMKYAVEMVE KLKSFDISMA CVGDMMHLAW
121: TGVEYATHVE EHKNCSDCKC TPLFQQKKSE RHWIFNVFDA MGKVPAGIMS GNNLWVGSWS
181: TCRKIDVVKN AQGQKWKGQY CLATIDAYER DNPLVYFGNM MSGPPDKHCY DKTVKNVTDD
241: GFCFALFPVL KFGVCMPNTC TNHDVKQMLS FAIRATEGAV GTKSVCNVDV ECRAESYSDA
301: MSENGLAMFA LYLLIATVVL VTFGTLYDLF IVSKAPQDEK NSSAFNHPFI KFILAFSMYT
361: NGSEILQSKK NDREINSLHG VRFLSMCWII LGHTYYYIGT SLTTDNLVPT LINFPKQFHT
421: QIIVQAPLAV DSFFFLSGML AAFSFFKKTM KADPNHPPKL SAFNWQTWPM YYYKRYIRIT
481: PTYIIVMLFD VTLFTYISNG PFWRPIERQG CSIAWWTNLI YLNNFLLQDQ ECCMGWTWYL
541: ANDMQFHIFL MPLLVIVFLK WGMKVGLGLS TGLIALSSLI RLIITQIYGY PPAPILTAKL
601: QIVYQLNDYW NDVYVRPYIR CTPFIVGIVV AYLLNAWTTR EQKDLKIKLE RRTVIICWCT
661: STVLGLYSVF GLYWFAKTGD ISKPWEILYT IFGTPAYALA LGWVVFACTT GNGGPVDTIL
721: SWRLFVPLSK ITFCAYLLHP IMLQIYNLSR PQPFHFTTFI QMIRYTVEAV FASYTIAFFF
781: SLAFEKPLNK IDEMLFNSKK MMNGENGNTT EMVPLNKIRN SD