1.A.142. The C20.5L Viroporin (C20.5L-VP) Family This family has been examined, first, showing that its characterized member is a small transmembrane protein of 49 aas and 1 N-terminal TMS (residues 6 - 26). Second, it has been shown to have ion channel activity (Basu et al. 2023). Third, its 3-D transmembrane structure has been predicted using alpha-fold.
References:
Basu, K., M. Krugliak, and I.T. Arkin. (2023). Viroporins of Mpox Virus. Int J Mol Sci 24:.
Examples:
TC#	Name	Organismal Type	Example
1.A.142.1.1	*Monkeypox virus (Mpox virus; Mpkv) viroporin of 49 aas and 1 N-terminal TMS. It forms an oligomeric transmembrane pore that transports ions (Basu et al.* 2023).**		Viroporin of Monkeypox virus

1.A.142.1.2	IMV protein (putatie viroporin) of 49 aas and 1 N-terminal TMS.		IMV protein of NY_014 poxvirus

1.A.142.1.3	IMV protein of 49 aas and 1 N-terminal TMS.		IMV protein of Raccoonpox virus