1.A.144.  The A15.5L Viroporin (A15.5L-VP) Family

This family has been examined, first, showing that its characterized member is a  small transmembrane protein of 73 aas and 1 TMS (residues 45 - 69). Second, it has been shown to have ion channel activity (Basu et al. 2023). Third, its 3-D transmembrane structure has been predicted using alpha-fold.


 

References:

Basu, K., M. Krugliak, and I.T. Arkin. (2023). Viroporins of Mpox Virus. Int J Mol Sci 24:.
McGilvray, P.T., S.A. Anghel, A. Sundaram, F. Zhong, M.J. Trnka, J.R. Fuller, H. Hu, A.L. Burlingame, and R.J. Keenan. (2020). An ER translocon for multi-pass membrane protein biogenesis. Elife 9:.
Examples:

TC#NameOrganismal TypeExample
1.A.144.1.1

The gp063 viroporin IMV membrane protein 12 of 73 aas and 1 TMS encompasing residues 45 - 69, thus being C-terminal.

gp063 viroporin protein of Monkeypox virus

 
1.A.144.1.2

gp063 viroporin Imv membrane protein of 63 aas and 1 C-terminal TMS.

gp063 viroporin of Pteropox virus

 
1.A.144.1.3

Uncharacterized protein of 69 aas with 1 C-terminal TMS.

UP of Bovine papular stomatitis virus

 

 
1.A.144.1.4

Uncharacterized protein of 65 aas with 1 C-terminal TMS.

UP of Flamingopox virus FGPVKD09