1.B.57 The Legionella Major-Outer Membrane Protein (LM-OMP) Family The genome of Legionella pneumophila reveals the presence of a large number of genes coding for eukaryotic-like proteins. Khemiri et al. (2008) identified proteins in L. pneumophila whose sequences share similarities with those of eukaryotic polypeptides (lpg0211, lpg1974 and lpg1982). In eukaryotes, the corresponding proteins (PBR, peripheral benzodiazepine receptor; VDAC, voltage-dependant anion channel; and CypD, cyclophilin D) participate in the formation of the mammalian mitochondrial permeability transition pore (MPTP), a complex involved in cell apoptosis. Lpg1974 is a major OMP of Legionella and may be a porin. Multiple paralogues are sometimes formed in a single bacterium.
This family belongs to the Outer Membrane Pore-forming Protein I (OMPP-I) Superfamily .
References:
Khemiri, A., T. Jouenne, and P. Cosette. (2008). Presence in Legionella pneumophila of a mammalian-like mitochondrial permeability transition pore? FEMS Microbiol. Lett. 278: 171-176.
Examples:
TC#	Name	Organismal Type	Example
1.B.57.1.1	Legionella Major OMP (LM-OMP) of 297 aas. It is a voltage-dependent, anion-selective ion permeable porin.	γ-Proteobacteria	*LM-OMP of Legionella pneumophila* (Q5ZU34)**

1.B.57.1.2	OMP of 404 aas	α-Proteobacteria	*OMP of Rhodopseudomonas palustris* (Q21BQ4)**

1.B.57.1.3	OMP of 392 aas	δ-Proteobacteria	*OMP of Pelobacter carbinolicus* (Q3A8N9)**

1.B.57.1.4	Putative porin of 397 aas	Planctomycetes	PP of Pirellula staleyi (Pirella staleyi)

1.B.57.1.5	Uncharacterized protein of 557 aas	Cyanobacteria	UP of Oscillatoriales cyanobacterium

Examples:
TC#	Name	Organismal Type	Example
1.B.57.2.1	OMP of 413 of aas	Planctomyocetes	*OMP of Gemmata obscuriglobus* (ZP_02735776)**

1.B.57.2.2	OMP of 403 aas	Planktomyocetes	*OMP Blastopirellula marina* (A3ZSY5)**

Examples:
TC#	Name	Organismal Type	Example
1.B.57.3.1	OMP of 430 aas	α-Proteobacteria	*OMP of Bradyrhizobium* sp. BTAi1 (A5EHQ1)**

1.B.57.3.2	Putative porin of 302 aas	Proteobacteria	Putative porin of Nitrobacter winogradskyi

Examples:
TC#	Name	Organismal Type	Example
1.B.57.4.1	Uncharacterized protein of 371 aas	Elusimicrobia	UP of Elusimicrobium minutum

1.B.57.4.2	Uncharacterized protein of 323 aas	Bacteroidetes	UP of Alistipes putredinis

1.B.57.4.3	Uncharacterized protein of 327 aas	Bacteroidetes	UP of Odoribacter splanchnicus

1.B.57.4.4	Uncharacterized protein of 326 aas. This protein is homologous to 8 and 9 repeats in TC protein #s 9.B.133.1.1 and 9.B.133.1.2, respectively in TC Blast searches.	Bacteroidetes	UP of Alistipes shahii

1.B.57.4.5	Uncharaterized protein of 382 aas	Bacteroidetes	UP of Pedobacter saltans

1.B.57.4.6	Uncharacterized protein of 388 aas	Bacteroidetes	UP of Prevotella melaninogenica