1.D.167. The Photomodulatable Stiff-Stilbene Based Bis(thio)urea Channel (PSS-Btc-Ch) Family

Wezenberg et al. 2021 demonstrated photocontrol of transmembrane transport and the membrane electrical potential using bis(thio)ureas derived from stiff-stilbene. They bind and transport anions such as chloride. The (Z)-isomers are much more active in transmembrane transport than the respective (E)-isomers. Both membrane transport and depolarization can be modulated upon irradiation, opening up new prospects toward light-based therapeutics (Wezenberg et al. 2021).

References:

Wezenberg, S.J., L.J. Chen, J.E. Bos, B.L. Feringa, E.N.W. Howe, X. Wu, M.A. Siegler, and P.A. Gale. (2021). Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas. J. Am. Chem. Soc. [Epub: Ahead of Print]