1.D.178.  The Semiaza-Bambusuril (Semiaza-Bambusuril) Family 

Semiaza-Bambus[6]urils efficiently transport anions across lipid membranes. A systematic modification of their lipophilic side chains to include various alkyl groups and thioethers revealed that the most efficient chloride transporters are those that agree with Lipinski's rule-of-lipophilicity, exhibiting clog Po/w values close to 5. Furthermore, vesicle anion-transport assays showed that these anion-transporters function independently of the cation. They exhibit high anion selectivity, NO₃^- > Br^- > Cl^- > SO₄^2-, in agreement with the Hofmeister series. These compounds may be used to allow for the design of highly specific anion transporters for biomedical applications (Khurana et al. 2022).

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