1.D.226. The L-Tyrosine-modified NanoChannel (TmNC) Family

Chiral L-tyrosine-modified nanochannels (L-Tyr nanochannels) are based on polyethylene terephthalate films, which can enhance the chiral recognition of propranolol isomers (R-/S-PPL) for transmembrane transport (Yang et al. 2023). Conventional fluorescence spectroscopy, patch-clamp technology, laser scanning confocal microscopy, and picoammeter technology have been employed to evaluate the performance of nanochannels. The results showed that the L-Tyr nanochannel have better chiral selectivity for R-/S-PPL compared with the L-tryptophan (L-Trp) channel, and the chiral selectivity coefficient is improved by about 4.2-fold (Yang et al. 2023).

References:

Yang, L., Z. Sun, S. Zhang, Y. Sun, and H. Li. (2023). Chiral Transport in Nanochannel Based Artificial Drug Transporters. Small 19: e2205274.