1.D.78.  The Acyclic 3-Aminobenzoate/Alanine Octapeptide (ACOC) Family 

Ion transporters have been developed from acyclic octapeptides comprising L/D-alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analogues through lipid vesicular membranes. Preliminary CD, XRD and computational studies suggest a 6-9 Å wide tetrameric ion channel as the active ion transporter (Benke and Madhavan 2013).


 

References:

Benke, B.P. and N. Madhavan. (2013). Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine. Chem Commun (Camb) 49: 7340-7342.