1.D.92. The Cyclic Peptide-Polymer Conjugate (CPPC) Family

Cyclic peptides (CPs) form artificial ion channels in lipid membranes. The design and synthesis of cyclic peptide-polymer conjugates (CPPCs) that can self-assemble within lipid bilayers into nanotubes mimicks naturally occurring membrane channels and pores. The pH-sensitive dye, carboxyfluorescein, can be encapsulated within the water pool of vesicles and used as an indicator of proton transport via these CPPCs (Binfield et al. 2018). The pH-sensitive dye, carboxyfluorescein, can be encapsulated within the water pool of the giant unilamellar vesicles and used as an indicator of proton transport.

References:

Binfield, J.G., J.C. Brendel, N.R. Cameron, A.M. Eissa, and S. Perrier. (2018). Imaging Proton Transport in Giant Vesicles through Cyclic Peptide-Polymer Conjugate Nanotube Transmembrane Ion Channels. Macromol Rapid Commun. [Epub: Ahead of Print]