1.G.22 The Cytomegalovirus (Human Herpesvirus 5)Glycoprotein gO (gO) Family 

Feng and Jia 2016 described the molecular mechanisms of glycoprotein-induced fusion and entry of herpesviruses. gO or gL in part serves this function in Cytomegalovirus. The heterodimer, glycoprotein H-glycoprotein L, is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL


 

References:

Feng, D. and R. Jia. (2016). [Molecular Mechanism of Glycoprotein-induced Cell-Cell Fusion of Herpesviruses]. Bing Du Xue Bao 32: 101-107.
Yue, Y., S.S. Zhou, and P.A. Barry. (2003). Antibody responses to rhesus cytomegalovirus glycoprotein B in naturally infected rhesus macaques. J Gen Virol 84: 3371-3379.
Examples:

TC#NameOrganismal TypeExample
1.G.22.1.1

The gO or gL glycoprotein fusogen of 278 aas and 3 TMSs, 1 N-terminal and 2 near the C-terminus (Feng and Jia 2016). The heterodimer glycoprotein H (742 aas; 2 TMSs, N- and C-terminal)-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB (907 aas; 3 TMSs, 1 N-terminal and 2 near the C-terminus; similar to gB of 1.G.10.1.1) and the heterodimer gH/gL.

gO of Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

 
1.G.22.1.2

Rhesus cytomegalovirus glycoprotein B of 854 aas and 3 TMSs, 1 N-terminal and 2 near the C-terminus of the protein. GpB is an envelope glycoprotein that forms spikes at the surface of virion envelope. It is essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans and is involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. It may be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress (Yue et al. 2003).

Gp3 of Rhesus cytomegalovirus