1.M.7. The Phage Mu Spanin (Spanin7) Family Spanins are components of spanin complexes that disrupts the host outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycan. The phage Mu spanins were characterized by Chamblee et al. 2022.
This family belongs to the Spanin Superfamily.
References:
Chamblee, J.S., J. Ramsey, Y. Chen, L.T. Maddox, C. Ross, K.H. To, J.L. Cahill, and R. Young. (2022). Endolysin Regulation in Phage Mu Lysis. mBio 13: e0081322.
Examples:
TC#	Name	Organismal Type	Example
1.M.7.1.1	Phage Mu spanin, Span1, of 128 aas and 1 N-terminal TMS. See Chamblee et al. 2022 for its identification. It may function with Span1.1. See the family description for more details. It is an inner membrane subunit, and its gene and protein designations are Mup23 and gp23.		Span1 of phage Mu

1.M.7.1.2	DUF2570 spanin of unknown function of 121 aas and one N-terminal TMS.		Spanin of Siphoviridae sp.

1.M.7.1.3	DUF2570 domain-containing protein of 130 aas and 1 N-terminal TMS.		DUF2570 domain protein of E. coli

1.M.7.1.4	Uncharacterized protein of 125 aas and 1 N-terminal TMS.		UP of Morganella morganii

1.M.7.1.5	DUF2570 domain-containing protein of 127 aas and 1 N-terminal TMS.		DUF2570 protein of Citrobacter portucalensis

1.M.7.1.6	DUF2570 domain-containing protein of 129 aas and 1 N-terminal TMS.		DUF2570 protein of Raoultella ornithinolytica