2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family
The KdgT permease of Erwinia chrysanthemi is the only well-characterized member of the KdgT family although homologues are present in many bacteria. Thus, members of the family are present both in Gram-negative and Gram-positive bacteria (Allen et al. 1989). The protein from E. chrysanthemi possesses 398 amino acids and probably traverses the membrane as α-helicies 10-12 times. Uptake is energized by proton symport (Condemine and Robert-Baudouy 1987).
The transport reaction catalyzed by KdgT is:
KDG (out) + H+ (out) ⇌ KDG (in) + H+ (in)
2-keto-3-deoxygluconate:proton symporter (Condemine and Robert-Baudouy 1987).
KdgT of Erwinia chrysanthemi
2-keto-3-deoxygluconate permease (KDG transporter), KdgT
KdgT of Escherichia coli
Probable galacturonate uptake porter of 330 aas and 10 TMSs (Pujic et al. 1998).
Probable galacturonate uptake porter of Bacillus subtilis
KdgT homologue of 315 aas and 10 TMSs.
KdgT homologue of Anaerococcus senegalensis
N-terminal KdgT domain with 10 TMS and a C-terminal N-acetyl transferase (NAT) domain. 462 aas total.
KdgT of Streptococcus pasteurianus
Putative 2-keto-3-deoxygluconate:proton symporter of 320 aas and 10 TMSs. This protein shows significant sequence similarity to members of family 2.A.98 (the PSE Famiy).
UP of Gardnerella vaginalis
Mitochondrial carrier, AMC2 or MC4, of 540 aas and
AMC2 of Plasmodium falciparum