2.A.107 The MntP Mn2+ exporter (MntP) Family

The MntP (YebN) family (SwissProt family UPF0059) is a small family of prokaryotic (bacterial and archaeal) proteins of about 200 residues with 6 putative TMSs. CDD recognized two DUF204 repeats, each repeat having 3 TMSs. One member of the family has been shown to export manganese ions (Waters et al. 2011).



This family belongs to the LysE Superfamily.

 

References:

Waters, L.S., M. Sandoval, and G. Storz. (2011). The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. J. Bacteriol. 193: 5887-5897.

Examples:

TC#NameOrganismal TypeExample
2.A.107.1.1

The manganese ion efflux pump, MntP (YebN).  Regulated by the MntR regulatory protein and the MntS sRNA (Waters et al., 2011). This family has been designated the DUF204 family.

Bacteria

YebN of E. coli

 
2.A.107.1.2

The Mth1812 of 184 aas and 6 TMSs.

Archaea

Mth1812 of Methanobacterium thermoautotrophicum

 
2.A.107.1.3

DUF204 homologue

Firmicutes

DUF204 homologue of Halobacillus halophilus

 
2.A.107.1.4

A manganese efflux pump of 184 aas and 6 TMSs.

Mn2+ exporter of Bacillus altitudinis

 
2.A.107.1.5

A manganese efflux pumpof 185 aas and 6 TMSs.

Mn2+ exporter of Bacillus subtilis

 
Examples:

TC#NameOrganismal TypeExample
2.A.107.2.1

Hypothetical protein of 188 aas

Firmicutes

HP of Halanaerobium hydrogeniformans

 
Examples:

TC#NameOrganismal TypeExample
2.A.107.3.1

Membrane protein of 210 aas

Firmicutes

Membrane protein of Bacillus subtilis