2.B.84. The bis-Amido Imadazole Receptor/Transporter (bAIR/T) Shinde and Talukdar 2019 have synthesised a series of bisamido-imidazole receptors (29a–f) shown in the figure below. These compounds were shown to function as H⁺/Cl⁻ co-transporters in an HPTS assay but were also shown to be capable of facilitating chloride/nitrate exchange using a lucigenin assay. A comparison of anion transport activity showed that compound 29a was the most effective transporter in this series (Davis et al. 2020). Fig. 16 HCl binding by the family of bis(amido)imidazoles 29.
References:
Davis, J.T., P.A. Gale, and R. Quesada. (2020). Advances in anion transport and supramolecular medicinal chemistry. Chem Soc Rev. [Epub: Ahead of Print]
Shinde, S.V. and P. Talukdar. (2019). Transmembrane H/Cl cotransport activity of bis(amido)imidazole receptors. Org Biomol Chem 17: 4483-4490.
Shinde, S.V., and P. Talukdar,. (2018). An anion receptor that facilitates transmembrane proton-anion symport by deprotonating its sulfonamide N-H proton. Chem Commun (Camb) 54: 10351-10354.