8.A.12 The ABC Bacteriocin Exporter Accessory Protein (BEA) Family

&9;The BEA family accesory proteins are small proteins of 127-174 amino acyl residues that function in conjunction with export porters of the ABC superfamily. They are found in Gram-positive bacteria and function in the export of bacteriocins. Without these accessory proteins, the ABC exporters are nonfunctional. BEA family proteins exhibit a single C-terminal, putative, transmembrane spanner.



Mètivier A., M-F. Pilet, X. Dousset, O. Sorokine, P. Anglade, M. Zagorec, J-C. Piard, D. Marion, Y. Cenatiempo and C. Fremaux (1998). Divercin V41, a new bacteriocin with two disulfide bonds produced by Carnobacterium divergens V41: primary structure and genomic organization. Microbiology 144: 2837-2844.

Marugg J.D., C.F. Gonzalez, B.S. Kunka, A.M. Ledeboer, M.J. Pucci, M.Y. Toonen, S.A. Walker, L.C. Zoetmulder and P.A. Vandenbergh (1992). Cloning, expression and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0. Appl. Environ. Microbiol. 58: 2360-2367.

McCormick, J.K., A. Poon, M. Sailer, Y. Gao, K.L. Roy, L.M. McMullen, J.C. Vederas, M.E. Stiles and M.J. Van Belkum (1998). Genetic characterization and heterologous expression of brochocin-C, and antibotulinal, two-peptide bacteriocin produced by Brochothrix campestris ATCC 43754. Appl. Environ. Microbiol. 64: 4757-4766.


TC#NameOrganismal TypeExample
8.A.12.1.1BrcD accessory protein to BrcT (the ABC brochocin-C exporter) Gram-positive bacteria BrcD of Brochothrix campestris
8.A.12.1.2PedC accessory protein to PedD (the ABC pediocin exporter) Gram-positive bacteria PedC of Pediococcus acidilactici