8.A.173.  The Tubulin (Tubulin) Family

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. It hydrolyzes GTP and interacts with several transport systems to regulate their activities. These include connexin 43, for which the gap junctional channel is regulated by tubulin (TC# 1.A.24.1.1), mitochondrial VDAC (1.B.8) where it also regulates metabolite and Ca2+ transport across the outer membrane (Rostovtseva et al. 2021), the K+ channel, TRESK-1 (TC# 1.A.1.8.1), and the dopamine transporter, DAT (TC# 2.A.22.1.3). There are many tubulin isoforms in any one organism.  


 

References:

Rostovtseva, T.K., S.M. Bezrukov, and D.P. Hoogerheide. (2021). Regulation of Mitochondrial Respiration by VDAC Is Enhanced by Membrane-Bound Inhibitors with Disordered Polyanionic C-Terminal Domains. Int J Mol Sci 22:.
Examples:

TC#NameOrganismal TypeExample
8.A.173.1.1

Tubulin α1A (TubA1A or TUBA3) of 451 aas.

Tubα1A of Homo sapiens

 
8.A.173.1.2

Tubulin B-1, TubB1, of 451 aas; 40% identical to TubA1.

TubB1 of Homo sapiens