8.A.207.  The Zip8 Regulator 2 (Zip8R2) Family

C9orf85 and CXorf38 are two previously uncharacterized human proteins associated with ZIP8 malfunction (Tan et al. 2022). The former protein has 179 aas and possibly one C-terminal TMS.  Human metal cation symporter ZIP8 (SLC39A8) is a member of the solute carrier family responsible for intracellular transport of essential micronutrients, including manganese, selenium, and zinc. Previously, Tan et al. 2022 established a ZIP8-knockout (KO) human cell model and explored how the expression of ZIP8 could contribute to a range of human diseases. C9orf85 and CXorf38 were amongst the top-10 most downregulated proteins in a Zip8 knockout mutant, and their expressions could be selectively induced by essential micronutrients. Analyses indicated a positive correlation between the gene expressions of ZIP8 and C9orf85 or CXorf38. The differentially expressed proteins identified in ZIP8-KO cells could be potential targets for diagnosing and/or treating human ZIP8-associated diseases, including malnutrition, viral infection, and cancers (Tan et al. 2022). Amoung it's homologs is E3 ubiquitin-protein ligase, TRIM52 isoform X1, of Homo sapiens and many others.

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