8.A.215. The Plasmalemma Vesicle-associated Protein (PLVAP) Family PLVAP proteins are endothelial cell-specific membrane proteins involved in the formation of the diaphragms that bridge endothelial fenestrae. They are also required for the formation of stomata of caveolae and transendothelial channels. They function in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. They play a specific role in embryonic development. Structural insights into PLVAP have been discussed, and implications for vascular endothelial diaphragms and fenestrae (Chang et al. 2023).
References:
Chang, T.H., F.L. Hsieh, X. Gu, P.M. Smallwood, J.M. Kavran, S.B. Gabelli, and J. Nathans. (2023). Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae. Proc. Natl. Acad. Sci. USA 120: e2221103120.
Examples:
TC#	Name	Organismal Type	Example
8.A.215.1.1	The Plasmalemma Vesicle-associated Protein, PLVAP, of 442 aas and one N-terminal TMS. See family description for details.		PLVAP of Homo sapiens

8.A.215.1.2	PLVAP of 529 aas and 1 N-terminal TMS.		*PLVAP of Oncorhynchus gorbuscha* (pink salmon)**

8.A.215.1.3	Plasmalemma vesicle associated protein a isoform X2 [Scophthalmus maximus		*PLVAP of Scophthalmus maximus* (turbot)**