8.A.225. The Vacuolar Protein Sorting-associated Protein (VPS) Family VPS proteins play roles in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. VPS8 is believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion, probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (Perini et al. 2014).
References:
Perini, E.D., R. Schaefer, M. Stöter, Y. Kalaidzidis, and M. Zerial. (2014). Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Traffic 15: 1366-1389.
Examples:
TC#	Name	Organismal Type	Example
8.A.225.1.1	VPS8 protein plays roles in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. It may act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion, probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion, probably in specific endosome subpopulations (Perini et al. 2014).		VPS8 of Homo sapiens

8.A.225.1.2	Uncharacterized protein of 1363 aas with 1 N-terminal TMS and possibly 4-5 more TMSs between residues 100 and 330.		*UP of Cercospora zeae-maydis SCOH1-5*

8.A.225.1.3	Vacuolar protein sorting-associated protein 8, VPS8, of 1957 aas with 1 N-terminal TMS as well as other peaks of hydrophobicity that might be TMSs.		VPS8 of Mortierella alpina

8.A.225.1.4	Golgi CORVET complex core vacuolar protein 8, VPS8, of 1901 aas with one N-terminal TMS.		VPS8 of Nitzschia inconspicua