8.A.240. The Metastasis-associated in Colon Cancer protein 1 (MACC1) Family The MACC1 protein acts as a transcription activator for MET and as a key regulator of HGF-MET signaling while promoting cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo (Stein et al. 2009). MACC1 regulates Cu homeostasis mediated by the cytochrome oxidase assembly protein, COX19 (see TC# 8.A.239) (Gao et al. 2024).
References:
Gao, S., H. Zhang, X. Zhang, J. Wang, W. Bai, and B. Jiang. (2024). COX19 Is a New Target of MACC1 and Promotes Colorectal Cancer Progression by Regulating Copper Transport in Mitochondria. J Nutr 154: 381-394.
Stein, U., W. Walther, F. Arlt, H. Schwabe, J. Smith, I. Fichtner, W. Birchmeier, and P.M. Schlag. (2009). MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat. Med. 15: 59-67.
Examples:
TC#	Name	Organismal Type	Example
8.A.240.1.1	The Metastasis-associated in Colon Cancer protein 1, MACC1 of 852 aas and several possible (but not established) TMSs (Gao et al. 2024). See family description for details as to how it regulates Cox19 (see TC family 8.A.239).		MACC1 of Homo sapiens

8.A.240.1.2	MACC1 protein of 842 aas and several possible TMSs. It is a positive regulator of transcription by RNA polymerase II. See family description for details.		*MACC1 protein of Sarcophilus harrisii* (Tasmanian devil) (Sarcophilus laniarius)**