8.A.248. The Ras-related Rab GTPase (RrRG) Family Rab GTPases play important roles in regulating many transport processes. These include transport between the golgi, endoplasmic reticulum and vesicles of eukaryotic cells. There are many RAB proteins which are annotated by number: Rab1a, Rab1b, Rab2a, Rab2b, Rab3a, Rab3b, Rab3c, Rab4a, Rab4b, Rab5a, Rab5b, Rab5c, etc. etc. There are more than 50 of them in UniProt in humans alone. Proteins in this family will be listed only for a few of these proteins here in TCDB. They regulate interactions between the golgi, the ER, the organelles, and intracellular vesicles in addition to other functions, influencing the activities of several independent transport systems (Parray 2025).
This family belongs to the GTPase, Type 1 .
References:
Parray, Z.A. (2025). A review on evolution, structural characteristics, interactions, and regulation of the membrane transport protein: The family of Rab proteins. Int J Biol Macromol 296: 139828. [Epub: Ahead of Print]
Examples:
TC#	Name	Organismal Type	Example
8.A.248.1.1	Rab12 of 244 aas		Rab12 of Homo sapiens

8.A.248.1.2	Rab7a of 207 aas.		Rab7a of Homo sapiens

8.A.248.1.3	Rab14 of 215 aas		Rab14 of Homo sapiens

8.A.248.1.4	Rab10 of 200 aas		Rab10 of Homo sapiens

8.A.248.1.5	Rab32 of 225 aas		Rab32 of Homo sapiens