8.A.256. The Transcutaneous auricular Vagus Nerve Stimulation (TaVNS) Family

TaVNS alleviates preeclampsia-induced vascular endothelial dysfunction via α7nAChR - IP3R1/GRP75/VDAC1 signal pathway. Endothelial dysfunction is considered to play a pivotal role in the pathogenesis of preeclampsia (PE). TaVNS is a potential non-pharmaceutical alternative treatment for PE. Zhao et al. 2025 explored the mechanisms of taVNS on endothelial dysfunction. taVNS may exert an anti-PE effect through ER-MITO interactions. These findings offer preliminary insights into PE pathogenesis, and suggest that the ACh/α7nAChR axis and IP3R1/GRP75/VDAC1 complex could be promising targets for future therapeutic investigation.

References:

Zhao, J., Y. Lei, C. Mu, Y. Wu, R. Fang, D. Wu, S. Xu, and H. Qiao. (2025). taVNS alleviates preeclampsia-induced vascular endothelial dysfunction via α7nAChR- IP3R1/GRP75/VDAC1 signal pathway. Inflamm Res 74: 133.