8.C.11. The MS-L6 OxPhos Inhibitor (MS-L6) Family

MS-L6 induces cell death in a variety of cancer cell lines, including B-cell and T-cell lymphomas as well as pediatric sarcoma. It is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and an uncoupling effect. Assuming that the latter effect is due to facilitating H+ fluxes across the inner mitochondrial membrane, it must also be an ionophore. This novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity (Al Assi et al. 2024).

inhibitor of oxidative phosphorylation

References:

Al Assi, A., S. Posty, F. Lamarche, A. Chebel, J. Guitton, C. Cottet-Rousselle, R. Prudent, L. Lafanechère, S. Giraud, P. Dallemagne, P. Suzanne, A. Verney, L. Genestier, M. Castets, E. Fontaine, M. Billaud, and M. Cordier-Bussat. (2024). A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity. Cell Death Dis 15: 311.