9.A.5 The Putative Arginine Transporter (ArgW) Family The putative arginine transporter (ArgW) of Shewanella oneidensis contains 452aas with 10 putative TMSs in a 4+2+4 arrangement and N- and C- termini predicted inside. The Geobacillus homologue, HisW, contains 441aas with 10 or 11 putative TMSs; both N- and C- termini are inside. It is called the COG3314 family or GATE Superfamily (Rodionov et al., 2009). The reaction believed to be catalyzed by ArgW is: arginine (out) → arginine (in)
References:
Ravcheev, D.A., A.A. Best, N. Tintle, M. Dejongh, A.L. Osterman, P.S. Novichkov, and D.A. Rodionov. (2011). Inference of the transcriptional regulatory network in Staphylococcus aureus by integration of experimental and genomics-based evidence. J. Bacteriol. 193: 3228-3240.
Rodionov, D.A., P. Hebbeln, A. Eudes, J. ter Beek, I.A. Rodionova, G.B. Erkens, D.J. Slotboom, M.S. Gelfand, A.L. Osterman, A.D. Hanson, and T. Eitinger. (2009). A novel class of modular transporters for vitamins in prokaryotes. J. Bacteriol. 191: 42-51.
Rodionov, D.A., P.S. Novichkov, E.D. Stavrovskaya, I.A. Rodionova, X. Li, M.D. Kazanov, D.A. Ravcheev, A.V. Gerasimova, A.E. Kazakov, G.Y. Kovaleva, E.A. Permina, O.N. Laikova, R. Overbeek, M.F. Romine, J.K. Fredrickson, A.P. Arkin, I. Dubchak, A.L. Osterman, and M.S. Gelfand. (2011). Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus. BMC Genomics 12Suppl1: S3.
Examples:
TC#	Name	Organismal Type	Example
9.A.5.1.1	*The putative arginine uptake porter, ArgP. Regulated by arginine repressor ArgR (Rodionov et al.* 2011)**	Bacteria	*ArgP of Shewanella oneidensis* (Q8EHH6)**

Examples:
TC#	Name	Organismal Type	Example
9.A.5.2.1	*The putative histidine uptake porter, HutP. Encoded in histidine utilization operons (Ravcheev et al.* 2011)**	Bacteria	HutP of Geobacillus kaustophilus (Q5L082)

9.A.5.2.2	*The putative histidine uptake porter, HutP. Encoded in histidine utilization operons and regulated by predicted histidine repressor HutR (Ravcheev et al.* 2011)**	Bacteria	HutP of Staphylococcus aureus (Q99WQ7)

Examples:
TC#	Name	Organismal Type	Example
9.A.5.3.1	Sporulation integral membrane protein, YlbJ	Bacteria	*YlbJ of Thermincola potens* (D5X8Q3)**

9.A.5.3.2	Sporulation integral membrane protein required for spore cortex formation; trascribed by sigma-E RNA Polymerase (Eichenberger et al., 2003). (408 aas; 10 TMSs; two repeats; Gate Superfamily).	Bacteria	*YlbJ of Bacillus subtilis* (O34765)**

Examples:
TC#	Name	Organismal Type	Example
9.A.5.4.1	5 TMS homologue of YlbJ (242 aas).	Bacteria	*5 TMS YlbJ homologue of Vibrio mimicus* (D2YRH2)**

9.A.5.4.2	The uncharacterized YjiH protein of 227 aas and 4 - 5 TMSs. Putative nucleoside recognition pore and gate family; putative inner membrane transporter.		YjiH of E. coli