9.A.70 The Mitochondrial Aspartate Amino Transferase (AAT) Family The mitochondrial AAT (GOT2) catalyzes the irreversible transamination of the L-tryptophan metabolite, L-kynurenine, to form kynurenic acid (KA), playing a key role in amino acid metabolism. It is important for metabolite exchange between mitochondria and cytosol and facilitates cellular uptake of long-chain free fatty acids (Zhou et al. 1998). It is regulated by AS160 which generally regulates energy utilization including Glut4 translocation to the plasma membrane (Mikłosz et al. 2016).
References:
Mikłosz, A., B. Łukaszuk, M. Żendzian-Piotrowska, K. Kurek, and A. Chabowski. (2016). The Effects of AS160 Modulation on Fatty Acid Transporters Expression and Lipid Profile in L6 Myotubes. Cell Physiol Biochem 38: 267-282.
Zhou, S.L., R.E. Gordon, M. Bradbury, D. Stump, C.L. Kiang, and P.D. Berk. (1998). Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. Hepatology 27: 1064-1074.
Examples:
TC#	Name	Organismal Type	Example
9.A.70.1.1	*Mitochondrial aspartate amino transferase of 430 aas and 1 TMS, AAT or GOT2. Plays a role in fatty acid transport (Zhou et al.* 1998; Mikłosz et al. 2016).**		GOT2 of Homo sapiens