9.B.116 The Transporter, YvqF (YvqF) Family The YvqF family includes thousands of sequenced proteins, all of which have an N-terminal transmembrane domain of probably of 2-4 TMSs (residues 1-~120) plus a C-terminal hydrophilic Duf2154 domain that includes a central semihydrophobic region of about 50 residues that is sometimes predicted to comprise an additional 2 TMSs. An example is YvqF of Streptococcus dysgalactiae (9.B.116.1.1). The Duf2154 domain may contain an internal repeat of about 44 aas. The function is unknown. However, this family may show some sequence similarity with the 2-TMS TC family 9.B.109, a family of putative archaeal holins.
Examples:
TC#	Name	Organismal Type	Example
9.B.116.1.1	Putative transporter, YvqF of 230 aasand 4 putative TMSs in a 2 + 2 TMS arrangement.	Bacteria	*YvqF of Streptococcus dysgalactiae* (C5WIF8)**

9.B.116.1.2	*LiaF of the lia* operon (246 aas)**	Bacteria	*LiaF of Bacillus thuringiensis* (F0PUM6)**

9.B.116.1.3	Uncharacterized protein of 205 aas and 2 TMSs. This protein shows appreciable sequence similarity with 9.B.109.1.1, possibly suggesting homology.		UP of Lactococcus garvieae

9.B.116.1.4	Cell wall-active antibiotics response protein of 261 aas and 4 N-terminal TMSs.		antibiotic response protein of Cohnella lubricantis

Examples:
TC#	Name	Organismal Type	Example
9.B.116.2.1	Cell wall active antibiotic response protein (CWARP)	Bacteria	*CWARP of Paenibacillus vortex* (E5Z496)**

Examples:
TC#	Name	Organismal Type	Example
9.B.116.3.1	4TMS YvqF homologue	Bacteria	*4TMS YvqF homologue of Dethiobacter alkaliphilus* (C0GCK7)**

9.B.116.3.2	4TMS YvqF homologue	Bacteria	*4TMS YvqF homologue of Pedobacter sp.* (A6ECX8)**

9.B.116.3.3	Uncharacterized protein of 230 aas and 4 N-terminal TMSs		UP of Tannerella forsythia

9.B.116.3.4	Uncharacterized protein of 180 aas and 2 N-terminal TMSs.		UP of Anaerolineales bacterium (marine sediment metagenome)