9.B.124 The DUF805 or PF05656 (DUF805) Family
The DUF805 family consists of small proteins (~ 110 to 180aas) with 3 or 4 TMSs. In E. coli, YhaH and YhaI are homologous proteins that are encoded by adjacent genes. They may encode a complete transport system as is often the case with SMR members of the DMT superfamily which can be either homodimeric or heterodimeric. In the latter case, the two homologoous genes usually map next to each other (Jack et al. 2001).
References:
Inner membrane protein, YhaI (118aas; 3 TMSs)
Bacteria
YhaI of E. coli (P64592)
Uncharacterized protein of 231 aas and 3 TMSs
UP of Candidatus Saccharibacteria bacterium
YhaH (121aas; 3 TMSs)
Bacteria
YhaH of E. coli (P64591)
Putative aminopeptidase C (128aas; 3 TMSs)
Bacteria
Aminopeptidase C of Aggregatibacter actinomycetemcomitans (H0KI06)
Hypothetical protein (130aas; 3 TMSs)
Bacteria
HP of Streptococcus salivarius (G2GUD4)
YhaH homologue of 191 aas and 3 C-terminal TMSs.
YhaH of Tistrella mobilis
Uncharacterized protein of 142 aas and 3 TMSs.
UP of Xylanimonas cellulosilytica
Uncharacterized protein of 9 TMSs with TMSs 1 - 3 showing seqence similarity with other members of the family, but the last 6 TMSs of unknown origin.
UP of Phocaeicola abscessus
Uncharacterized protein of 191 aas and 3 TMSs
UP of Klebsiella oxytoca
Uncharacterized protein of 328 aas and 8 TMSs in a 4 + 4 TMS arrangement.
UP of Lactobacillus rhamnosus
Uncharacterized protein of 135 aas and 4 TMSs.
UP of Asticcacaulis biprosthecum
Uncharacterized protein of 147 aas and 4 TMSs
Proteobacteria
UP of E. coli
Uncharacterized protein of 150 aas and 4 TMSs
UP of Asticcacaulis benevestitus