9.B.143 The 6 TMS DUF1275/PF06912 (DUF1275) Family
Many bacterial DUF1275 family proteins are retrieved in PSI BLAST searches with iterations. It is a large family with members having a fairly uniform topology of 6 TMSs as expected for half-sized protein members of the MFS. Some members are encoded by a gene adjacent to a probable YtcJ-like metalo-amido-hydrolase suggesting a role in uptake of peptides or other amido compounds or efflux of their hydrolysis products.
DUF1275 homologue of 245 aas and 6 TMSs
Proteobacteria
DUF1275 protein of Burkholderia cenocepacia
Permease
Proteobacteria
Permease of Acinetobacter haemolyticus
Hypothetical protein of 235 aas and 6 TMSs
Firmicutes
Hypothetical protein of Streptococcus pyogenes
Membrane protein
Firmicutes
Membrane protein of Coprococcus catus
Duf1275 homologue
Archaea
Duf1275 homologue of Methanosarcina mazei
PF06912 homologue of 227 aas and 6 TMSs
Proteobacteria
PF06912 homologue of Enterbacteriaceae bacterium
Putative permease of 261 aas and 6 TMSs.
Putative permease of Labilithrix luteola
Putative permease of 268 aas and 6 TMSs containing the DUF1275 domain.
Putative permease of Cupriavidus metallidurans
Putative permease of 251 aas and 6 TMSs
Putative permease of Formosa agariphila
Putative permease of 250 and 6 TMSs containing the DUF1275 domain.
Putative permease of Sandaracinus amylolyticus
Putative DUF1275 6 TMS domain protein (N-terminal) with a C-terminal 3 TMS YkvA (DUF1232) domain of unknown function, found in bacteria and archaea.
Putative permease of Cupriavidus metallidurans
Uncharacterized protein of 250 aas and 6 TMSs
UP of Emiliania huxleyi
UPF0700 family protein, YoaK
Firmicutes
YoaK of Bacillus subtilis
Uncharacterized protein of 270 aas and 6 or 8 TMSs. There appears to be an internal repeat where in 3 or 4 TMS repeat until has 4 peaks of hydrophobicity with the second peak is relatively small.
Actinobacteria
UP of Bifidobacterium bifidum
Uncharacterized protein of 236 aas and 6 TMSs.
Actinobacteria
UP of Amycolatopsis mediterranei
Putative permease of 227 aas and 6 TMSs
Putative permease of Rhodococcus wratislaviensis
Putative permease of 204 aas and 7 TMSs containing the DUF1275 domain.
Putative permease of Leucobacter chironomi
Putative permease of 218 aas and 6 TMSs containing the DUF1275 domain.
Putative permease of Conexibacter woesei
Putative permease of 249 aas and 7-8 TMSs containing the DUF1275 domain.
Putative permease of Methylobacterium extorquens
DUF1275 protein of 249 aas and 6 TMSs
Fungi
DUF1275 protein of Aspergillus kawachii
Fungal DUF1275 homologue of 304 aas and 6 - 8 TMSs.
Fungi
DUF1275 homologue of Cryptococcus (Filobasidiella) neoformans
Uncharacterized protein of 275 aas and 6 TMSs
UP of Neosartorya fumigata (Aspergillus fumigatus)