9.B.154 The Putative Holin-2 (PH-2) Family

As of early 2016, functional data is not currently available for members of the PH-2 family. However, the PH-2 family is large with members from a wide variety of bacteria.  These proteins are of 130 - 210 aas and may have 1 or 2 TMSs.


 

References:

Xu, Q., A. Bateman, R.D. Finn, P. Abdubek, T. Astakhova, H.L. Axelrod, C. Bakolitsa, D. Carlton, C. Chen, H.J. Chiu, M. Chiu, T. Clayton, D. Das, M.C. Deller, L. Duan, K. Ellrott, D. Ernst, C.L. Farr, J. Feuerhelm, J.C. Grant, A. Grzechnik, G.W. Han, L. Jaroszewski, K.K. Jin, H.E. Klock, M.W. Knuth, P. Kozbial, S.S. Krishna, A. Kumar, D. Marciano, D. McMullan, M.D. Miller, A.T. Morse, E. Nigoghossian, A. Nopakun, L. Okach, C. Puckett, R. Reyes, C.L. Rife, N. Sefcovic, H.J. Tien, C.B. Trame, H. van den Bedem, D. Weekes, T. Wooten, K.O. Hodgson, J. Wooley, M.A. Elsliger, A.M. Deacon, A. Godzik, S.A. Lesley, and I.A. Wilson. (2010). Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J. Mol. Biol. 396: 31-46.
Examples:

TC#NameOrganismal TypeExample
9.B.154.1.1

Putative holin of 167 aas and 2 TMSs

Bacteroidetes

Holin of Bacteroides fragilis

 
9.B.154.1.10

Uncharacterized protein of 161 aas and 2 TMSs. The two TMSs show 42% identity with TMSs 9 - 10 of the 12 TMS protein with TC# 3.A.1.147.8.

UP of Planctomycetes bacterium

 
9.B.154.1.11

Uncharacterized protein of 159 aas and 2 TMSs

UP of Rathayibacter toxicus

 
9.B.154.1.12

PH domain-containing protein of 312 aas and 2 TMSs which are not adjacent to each other.

PH domain protein of Opitutus terrae

 
9.B.154.1.2

Putative holin of 168 aas and 2 TMSs

Bacteroidetes

Holin of Bacteroides salanitronis

 
9.B.154.1.3

Putative holin of 174 aas

Chloroflexi

Holin of Roseifoexus castenhalzii

 
9.B.154.1.4

Putative holin of 129 aas and 1 TMS

Proteobacteria

Holin of Cupriavidus (Ralstonia) metallidurans

 
9.B.154.1.5

Putative holin of 161 aas and 1 TMS

Verrucomicrobia

Holin of Opitutus terrae

 
9.B.154.1.6

Putative holin of 208 aas and 2 TMSs

Planctomycetes

Holin of Pirellula staleyi

 
9.B.154.1.7

Uncharacterized protein of 180 aas and 2 N-terminal adjacent TMSs, folllowed by about 100 residues comprising a hydrophilic bacterial PH (pleckstrin homology)-like domain (pfam03703), present in bacterial membrane proteins PH domains are ubiquitous, and form a dome-shaped, oligomeric ring with C(5) symmetry (Xu et al. 2010).

UP of Candidatus Thorarchaeota archaeon AB_25

 
9.B.154.1.8

Uncharacterized membrane-flanked domain-containing protein of 171 aas and 2 TMSs.

UP of Halovivax asiaticus

 
9.B.154.1.9

Uncharacterized protein of 481 aas and 6 TMSs in a 2 + 2 + 2 TMS arrangement with an probable HP-like domain between the 3 pairs of TMSs.

UP of Amycolatopsis ruanii

 
Examples:

TC#NameOrganismal TypeExample