9.B.160. The Colicin V Production (CvpA) Family Members of the CvpA family are not well characterized. They consist of proteins of variable sizes: 150 - 170; 200 - 240; and ~400 aas with 4 or 5 TMSs. The large protein of 396 aas and an N-terminal domain of 4 TMSs (TC# 9.B.160.1.10) has this hydrophobic domain followed by a hydrophilic protease domain. Members of this family, having the 4 or 5 TMS hydrophobic domain, occur in a wide range of bacteria.
References:
Fath, M.J., H.K. Mahanty, and R. Kolter. (1989). Characterization of a purF operon mutation which affects colicin V production. J. Bacteriol. 171: 3158-3161.
Examples:
TC#	Name	Organismal Type	Example
9.B.160.1.1	Colicin V production protein, CvpA of 234 aas and 4 TMSs.	Proteobacteria	CvpA of Acrobacter butzleri

9.B.160.1.10	CvpA of 394 aas and 4 N-terminal TMSs. The C-terminal hydrophilic domain appears to be homologous to proteases.	Actinobacteria	CvpA of Kocuria rhizophila

9.B.160.1.11	CvpA of 166 aas and 4 TMSs	Spiroahaetes	CvpA of Treponema primitia

9.B.160.1.12	CvpA of 163 aas and 4 TMSs	Firmicutes	CvpA of Halothermothrix orenii

9.B.160.1.13	CvpA of 170 aas and 4 TMSs	Synergistetes	CvpA of Aminobacterium colombiense

9.B.160.1.14	Uncharacterized protein of 227 aas and 4 TMSs	Proteobacteria	UP of Magnetospirillum gryphiswaldense

9.B.160.1.15	Uncharacterized protein of 167 aas and 4 TMSs	Proteobacteria	UP of Lawsonia intracellularis

9.B.160.1.16	*Colicin V production protein of 162 aas and 5 TMSs, CvpA (Fath et al.* 1989).**		CvpA of E. coli

9.B.160.1.2	CvpA family protein of 206 aas and 4 TMSs.	Proteobacteria	CvpA protein of Campylobacter concisus

9.B.160.1.3	CvpA of 233 aas and 4 TMSs.	Proteobacteria	CvpA of Helicobacter pylori

9.B.160.1.4	CvpA of 163 aas and 4 or 5 TMSs	Proteobacteria	CvpA of Methylotenera mobilis

9.B.160.1.5	CvpA of 173 aas and 4 TMSs	Proteobacteria	CvpA of Desulfovibrio desulfuricans

9.B.160.1.6	CvpA of 182 aas and 5 TMSs	Bacteroidetes	CvpA of Zunongwangia profunda

9.B.160.1.7	CvpA of 192 aas and 4 TMSs	Acidobacteria	CvpA of Granulicella tundricola

9.B.160.1.8	CvpA of 164 aas and 5 TMSs	Proteobacteria	CvpA of Photobacterium profundum

9.B.160.1.9	CvpA of 170 aas and 5 TMSs	Chloroflexi	CvpA of Herpetosiphon aurantiacus