9.B.237. The Ubiquitous Uncharacterized 7 TMS Protein-1(UUP1) Family
This family consists of proteins from uncultured bacteria as well as well characterized bacterial and archaeal phyla. They all appear to have a single N-terminal TMS followed by a hydrophilic domain, either short (<50 residues) or long >300 residues, followed by a C-terminal 6 TMS domain, where all 6 TMSs appear to be present together, but in three groups of closely clustering sets of 2 TMSs. Some of these proteins may lack the N-terminal hydrophilic domain, thus having only 6 TMSs. Others have all 7 TMSs N-terminal with a long C-terminal hydrophilic domain. Many of these protein are annotated 'Gonadoliberin III-like protein' implying the presence of eukaryotic homologues.
Uncharacterized protein of 298 aas and 7 TMSs in a 1 + 6 arrangement.
UP of Candidatus Beckwithbacteria bacterium
Uncharacterized protein of 531 aas and 8 TMSs in a 1 + 7 arrangement.
UP of Aquimarina aggregata
Uncharacterized protein of 511 aas and 7 TMSs with one N-terminal TMS, a large (~300 residue) hydrophilic domain, and a C-terminal 6 TMS domain.
UP of Pseudomonas fluorescens
RimK domain protein ATP-grasp of 584 aas and 7 N-terminal TMSs.
RimK daomin protein of Halobacterium sp. DL1
Uncharacterized protein of 555 aas and 7 TMSs.
UP of candidate division SR1 bacterium
Inactive transglutaminase fused to 7 transmembrane helices. This protein has the topology typical of this family with 1 N-terminal domain and 6 or 7 C-terminal TMSs.
UP of Vibrio hangzhouensis