9.B.241. The Prenyl Transferase (UbiA) Family
This family includes members that are of variable sizes and numbers of TMSs. Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. These proteins may contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.
Uncharacterized protein of 308 aas and 10 TMSs in a pattern of 2 + 2 + 2 + 2 + 2 TMSs. This protein is likely to be a prenyl transferase, possibly a 4-hydroxybenzoate polyprenyltransferase. It is in a huge ubiquitous family of prenyl transferases.
UP of Candidatus Beckwithbacteria bacterium
Uncharacterized protein of 473 aas and 7 C-terminal TMSs
UP of Caballeronia grimmiae
Uncharacterized putative 4-hydroxybenzoate octaprenyltransferase
UP of Thermococcus sibiricus
4-Hydroxybenzoate polyprenyltransferase-like protein prenyltransferase of 284 aas and 9 TM
UbiA-like protein of Candidatus Saccharibacteria bacterium
Uncharacterized protein of 233 aas and 6 - 7 TMSs.
UP of Aequorivita vladivostokensis
Prenyltransferase of 240 aas and 5 - 6 TMSs.
PT of Phellinus noxius
Prenyltransferase UbiA of 247 aas and 6 - 7 TMSs.
UbiA of Methanococcoides burtonii
Geranylgeranylglycerol-phosphate geranylgeranyltransferase of 283 aas and 9 TMSs.
UbiA family of Natronobacterium gregoryi
4-hydroxybenzoate octaprenyltransferase of 290 aas and 9 TMSs.
4-Hydroxybenzoate octaprenyltransferase of Seinonella peptonophila
UbiA prenyltransferase family proteinof 270 aas and 9 TM
Prenyltransferase of Lokiarchaeum sp. GC14_75