9.B.245.  The 10 TMS Uncharacterized DUF2776 (DUF2776) Family 

This family includes members with 10 TMSs in a 4 + 2 + 4 arrangement.  Several fragmentary proteins were also identified, but it is not known if these represent the existence of shorter homologues or incomplete sequences.


 

References:

Anderson, M.A., M.D. Mann, M.A. Evans, and R.L. Sparks-Thissen. (2017). The inner membrane protein YhiM is necessary for Escherichia coli growth at high temperatures and low osmolarity. Arch. Microbiol. 199: 171-175.
Examples:

TC#NameOrganismal TypeExample
9.B.245.1.1

DUF2776 protein of 348 aas and 10 TMSs in a 4 + 2 + 4 arrangement.

DUF3776 protein of Alistipes timonensis

 
9.B.245.1.2

Uncharacterized inner membrane protein, YhiM, that confers acid, heat and osmotic pressure resistance; of 350 aas and 10 TMSs (Anderson et al. 2017). This protein may play a role in cobalamin biosynthesis (see TC# 9.B.125.1.2).

YhiM of Escherichia coli

 
9.B.245.1.5

Uncharacterized DUF2776 protein of 351 aas and 10 TMSs in a 4 + 2 + 4 TMS arrangement.

UP of Aeriscardovia sp. (gut metagenome)