9.B.265. The Vitamin K Epoxide Reductase (VKER) Family The members of this family are between about 140 aas and about 600 aas in length. They have 4, 5 or 6 TMSs which for the small proteins encompase the whole protein, but for the larger proteins are always N-terminal. They all show sequence similarity in their transmembrane domain, not in their C-terminal hydrophilic domains which are often very different in sequence. Some have a C-terminal reductase domain and have been assigned to the bacterial VKER Family. Many clearly do not function in this capacity. There is no evidence that they function in transport.
Examples:
TC#	Name	Organismal Type	Example
9.B.265.1.1	Uncharacterized protein of 205 aas and 5 or 6 TMSs		UP of Candidatus Saccharibacteria bacterium

9.B.265.1.2	Vitamin K epoxide reductaseof 204 aas and 5 or 6 TMSs.		Reductase of Microbacterium hominis

9.B.265.1.3	Uncharacterized vitamin K epoxide reductaseof 170 aas and 4 TM		UP of Monashia flava

9.B.265.1.4	Uncharacterized protein of 143 aas and 4 TMSs.		UP of Anaerolinea thermolimosa

9.B.265.1.5	Uncharacterized dihydroorotate dehydrogenase (quinone) of 508 aas and 4 or 5 N-terminal TMSs that are sequence similar to the other members of this family.		UP of Candidatus Roizmanbacteria bacterium

9.B.265.1.6	Uncharacterized protein of 322 aas with an N-terminal 5 TMSs.		UP of Spirulina subsalsa

9.B.265.1.7	Uncharacterized protein of 394 aas with an N-terminal 5 TMS domain showing similarity to other members of this family.		UP of Candidatus Blackallbacteria bacterium