9.B.285. The 4 TMS Phage Infection Protein (possibly involved in LPS export) (4PIP) Family This is the DUF4345 family, members of which probably all have 4 TMSs, although several members are predicted to have 3 TMSs, where the central two TMSs of the 4 TMS proteins are predicted to be one TMS. The family is quite large with numerous members from a wide variety of bacteria. One of them, (9.B.285.1.1) been shown to be essential for phage infection in Agrobacterium, and it may play a role in LPS biosynthesis or export (Gonzalez et al. 2018).
References:
Gonzalez, F., R.F. Helm, K.M. Broadway, and B.E. Scharf. (2018). More than rotating flagella: LPS as a secondary receptor for flagellotropic phage 7-7-1. J. Bacteriol. [Epub: Ahead of Print]
Examples:
TC#	Name	Organismal Type	Example
9.B.285.1.1	DUF4345 domain containing protein of 128 aas and 4 TMSs. This protein has been shown to be essntial for phage infection and may play a role in lipopolysaccharide synthesis or export (Gonzalez et al. 2018).		DUF4345 protein of Agrobacterium sp. (strain H13-3) (Rhizobium lupini)

9.B.285.1.2	DUF4345 protein of 120 aas and 4 TMSs.		DUF4345 protein of Ruegeria meonggei

9.B.285.1.3	DUF4345 domain-containing proteinof 121 aas and 4 TMSs.		DUF4345 protein of Pseudonocardia alni

9.B.285.1.4	DUF4345 domain-containing protein of 127 aas and 4 TMSs.		DUF4345 protein of Hyphomonas chukchiensis

9.B.285.1.5	DUF4345 domain-containing protein of 118 aas and 3 or 4 TMSs.		*DUF4345 protein of Leptolyngbya* sp. JSC-1**

9.B.285.1.6	DUF4267 domain-containing proteinof 124 aas and 4 TM		DUF4267 protein of Nonomuraea candida

9.B.285.1.7	DUF4345 domain-containing proteinof 142 aas and 4 TM		DUF4345 protein of Thioclava sediminum

9.B.285.1.8	Uncharacterized protein BRC61_02080of 166 aas and 3 TMSs.		UP of Halobacteriales archaeon

Examples:
TC#	Name	Organismal Type	Example
9.B.285.2.1	Uncharacterized protein of 130 aas and 4 TMSs		UP of Chloroflexi bacterium

9.B.285.2.2	Uncharacterized protein of 128 aas and 4 TMSs		UP of Candidatus Thorarchaeota archaeon SMTZ-45 (sediment metagenome)

9.B.285.2.3	Uncharacterized protein of 128 aas and 4 TMSs		UP of Lokiarchaeum sp. GC14_75 (marine sediment metagenome)

9.B.285.2.4	Uncharacterized protein of 126 aas and 4 TMSs		UP of Candidatus Woesearchaeota archaeon

9.B.285.2.5	Uncharacterized protein of 275 aas and 8 TMSs in a 4 + 4 TMS arrangement.		UP of Crenarchaeota archaeon (soil metagenome)

9.B.285.2.6	Uncharacterized protein of 135 aas and 4 TMSs		UP of Spirochaetae bacterium HGW-Spirochaetae-5 (groundwater metagenome)

9.B.285.2.7	Uncharacterized protein of 189 aas and 6 TMSs in a 2 + 2 + 2 arrangement.		UP of Beduini massiliensis