9.B.395. The Uncharacterized Prokaryotic Membrane Protein (UPMP) Family Members of the UPMP family are integral membrane proteins with 6 or 7 TMSs in a 5+ 1 or 6 + 1 topology, where the N-terminal TMSs are present in a cluster, followed by a hydrophilic region and then a C-terminal TMS. Most protein homologs in the NCBI database are referred to as "hypothetical proteins".
Examples:
TC#	Name	Organismal Type	Example
9.B.395.1.1	Uncharacterized putative Na⁺/H⁺ antiporter of 300 aas and 6 or 7 TMSs in a 5 or 6 + 1 TMS arrangement. In the entire NCBI database, this is the only homologue that is annotated as a Na⁺/H⁺ antiporter, so it may be an error of annotation.		Member of family 9.B.395 of Psychromonas ingrahamii

9.B.395.1.2	Uncharacterized protein of 302 aas and 6 TMSs in a 5 + 1 TMS arrangement.		UP of Rhodovastum atsumiense

9.B.395.1.3	Uncharacterized protein of 297 aas and possibly 5 or 6 + 1 TMSs.		UP of Vibrio superstes

Examples:
TC#	Name	Organismal Type	Example
9.B.395.2.1	Uncharacterized protein of 318 aas and possibly 6 TMSs in a 1 + 4 + 1 TMS arrangement.		UP of Leptotrichia trevisanii

9.B.395.2.2	Uncharacterized protein of 278 aas and 6 putative TMSs in a 5 + 1 TMS arrangement.		UP of Armatimonadetes bacterium (aquatic metagenome)

Examples:
TC#	Name	Organismal Type	Example
9.B.395.3.1	Uncharacterized protein of 240 aas and 2 possibleTMSs near the N-terminus of the protein.		UP of Cichorium endivia

9.B.395.3.2	Pentapeptide repeat-containing protein,PPRP, of 240 aas and one N-terminal TMS and possibly one central TMS.		PRPP of Candidatus Eremiobacteraeota bacterium