9.B.8 The DUF2157 (DUF2157) Family The DUF2157 family consists of many proteins of 10, 12 and 14 TMSs with no extended hydrophilic domains, but some homologues have 19, 21 or 22 TMSs. They occur largely in bacteria although archaeal homologues have been detected. Some homologues are annotated as Brp/Blh family β-carotene 15,15' monoxygenase (see TC# 9.B.8.1.4). Others are annotated 'carotenoid bisynthesis protein'. These proteins may be glycosyltransferases distantly related to those of TC family 9.B.142.
Examples:
TC#	Name	Organismal Type	Example
9.B.8.1.1	DUF2157 homologue of 347 aas and 10 TMSs.	Chlamydiae	DUF2157 homologue of 347 aas and 10 TMSs of Parachlamydia acanthamoebae

9.B.8.1.10	Uncharacterized protein of 395 aas and 10 TMSs in a 5 + 5 arrangement.	Synergistetes	Synergistetes bacterium SGP1

9.B.8.1.11	Uncharacterized protein of 368 aas and 12 TMSs	Acidobacteria	UP of Solibacter usitatus

9.B.8.1.2	DUF2157 homologue of 365 aas and 10 TMSs	Cyanobacteria	*DUF2157 of Synechocystis* sp. strain PCC 6803 (P73022)**

9.B.8.1.3	DUF2157 homologue of 309 aas and 10 TMSs	β-Proteobacteria	*DUF2157 homologue of Methylotenera mobilis* (C6WV07)**

9.B.8.1.4	DUF2157 homologue of 357 aas and 12 TMSs. Annotated as Brp/Blh family β-carotene 15,15' monoxygenase.	Firmicutes	DUF2157 homologue of Sporosarcina newyorkensis (F9DST2)

9.B.8.1.5	DUF2157 homologue of 315 aas and 10 TMSs.	Acidobacteria	*DUF2157 homologue of Acidobacterium* sp. (E8WXN7)**

9.B.8.1.6	DUF2157 homologue of 366 aas and 12 TMSs	Archaea	*DUF2157 homologue of Natronomonas pharaonis* (Q3ITE7)**

9.B.8.1.7	DUF2157 homologue of 466 aas and 14 TMSs	Cyanobacteria	*DUF2157 of Microcoleus vaginatus* (F5UCB5)**

9.B.8.1.8	Uncharacterized protein of 431 aas	Proteobacteria	UP of Parvibaculum lavamentivorans

9.B.8.1.9	Uncharacterized protein of 364 aas and 12 TMSs	Proteobacteria	UP of Rhizobium etli

Examples:
TC#	Name	Organismal Type	Example
9.B.8.2.1	Uncharacterized protein of 399 aas and 12 TMSs	Spirochaetes	UP of Leptospira interogans

9.B.8.2.10	Permease of 570 aas and 19 TMSs	Fusobacteria	Permease of Fusobacterium nucleatum

9.B.8.2.11	Uncharacteried protein of 831 aas and 21 TMSs	Proteobacteria	UP of Pasteurella dagmatis

9.B.8.2.2	Uncharacterized protein of 379 aas and 12 TMSs	Proteobacteria	UP of Magnetococcus marinus

9.B.8.2.3	Uncharacterized protein of 710 aas and 21 TMSs	Firmicutes	UP of Bacillus megaterium

9.B.8.2.4	Uncharacterized protein of 472 aas and 12 TMSs	Euryarchaeota	UP of Archaeoglobus sulfaticallidus

9.B.8.2.5	Uncharacterized protein of 516 aas and 19 TMSs	Proteobacteria	UP of Acinetobacter baumannii

9.B.8.2.6	Uncharacterized protein of 337 aas and 10 TMSs	Proteobacteria	UP of Myxococcus xanthus

9.B.8.2.7	Uncharacteerized protein of 876 aas and 22 TMSs	Proteobacteria	UP of Achromobacter xylosoxidans

9.B.8.2.8	Uncharacterized protein of 336 aas and 9 or 10 putative TMSs	Chloroflexi	UP of Herpetosiphon aurantiacus

9.B.8.2.9	Uncharacterized protein of 313 aas and 9 TMSs	Bacteroidetes	UP of Fluviicola taffensis

Examples:
TC#	Name	Organismal Type	Example
9.B.8.3.1	Uncharacterized protein of 383 aas and 12 TMSs	Archaea	UP of Methanosarcina acetivorans

9.B.8.3.2	Uncharacterized protein of 327 aas and 10 TMSs	Spirochaetes	UP of Brachyspira intermedia (Serpulina intermedia)

9.B.8.3.3	Uncharacterized protein of 344 aas and 8 - 10 TMSs	Bacteroidetes	UP of Runella slithyformis

9.B.8.3.4	Uncharacterized protein of 347 aas and 10 TMSs	Proteobacteria	UP of Klebsiella pneumoniae

Examples:
TC#	Name	Organismal Type	Example
9.B.8.4.1	Uncharacterized protein of 426 aas and 14 TMSs	Bacteroidetes	UP of Haliscomenobacter hydrossis

9.B.8.4.2	Uncharacterized protein of 605 aas and 14 TMSs	Firmicutes	UP of Megaspheaera elsdenii

Examples:
TC#	Name	Organismal Type	Example
9.B.8.5.1	Uncharacterized protein of 336 aas and 10 TMSs	*Deinococcus/Thermus*	UP of Deinococcus deserti

Examples:
TC#	Name	Organismal Type	Example
9.B.8.6.1	Uncharacterized protein of 310 aas and 10 TMSs	Proteobacteria	UP of Granulibacter bethesdensis

9.B.8.6.2	Uncharacterized protein of 399 aas and 12 TMSs	Proteobacteria	UP of Octadecabacter antarcticus

Examples:
TC#	Name	Organismal Type	Example
9.B.8.7.1	NnrS family protein of 404 aas and 12 TMSs	Proteobacteria	NnrS family protein of Ralstonia pickettii

Examples:
TC#	Name	Organismal Type	Example
9.B.8.8.1	Carotenoid biosynthesis protein (CBP) of 303 aas and 9 TM		CBP of Candidatus Prometheoarchaeum syntrophicum

9.B.8.8.2	Uncharacterized protein of 220 aas and 7 TMSs		UP of Candidate division WOR_3 bacterium SM23_60 (sediment metagenome)