YiaH 10 (5+5?) TMS transmembrane protein (331aas) (The O-acetyltransferase of enterobacterial common antigen (ECA). Exhibits some similarity with TC# 2.A.36.1.7)

Bacteria

YiaH of E. coli K12 (P37669)

Acyltransferase 3 of 371 aas and 10 TMSs

Proteobacteria

UP of Desulfobulbus propionicus

Putative acyltransferase of 363 aas and 10 TMSs.

Acyltransferase of Slackia exigua

Uncharacterized protein of 369 aas and 10 TMSs.

UP of Clostridium sp. CAG:167

Phage putative 10 TMS, O157 antigen acylating, O-acetyltransferase, Oac. Acetylation blocks superinfection (Perry et al., 2009).

Virus

O-antigen transferase, Oac, of E. coli O157 phage ΦV10. (Q286Z2)

The archaeal protein, Msp1344 (10TMSs)

Archaea

Hypthetical protein, Msp1344 of Methanosphaera stadtmanae (Q2NEN2)

Putative fucose 4-O acetylase (346aas; 10 putative TMSs)

Bacteria

Fucose 4-O acetylase of Vibrio cholerae (C2ITH3)

Acyltransferase 3 of 347 aas and 10 TMSs

Firmicutes

Acyltransferase 3 of Thermoanaerobacterium saccharolyticum

Intercellular adhesion protein C of 387 aas and 11 TMSs

Spirochaetes

Adhesion protein C of Leptospira interrogans

Polysaccharide adhesin export protein of 350 aas and 10 TMSs, IcaC.  Involved in polysaccharide intercellular adhesin (PIA) export and biofilm formation (Hennig et al. 2007). IcaC binds succinate and may be an  O-succinyltransferase (Prabu et al. 2022).

Firmicutes

IcaC of Staphylococcus aureus

Uncharacterized protein of 358 aas and 11 putative TMSs.

Spirochaetes

UP of Leptospira biflexa

Uncharacterized protein of 369 aas and 11 TMSs.

Firmicutes

UP of Clostridium cellulovorans

Putative O-acyltransferase homologue (Oac7) (702aas; 14 putative TMSs)

Eukaryotes

Oac7 of Caenorhabditis elegans (O45283)

Transmembrane acyl transferase of 687 aas and 13 putative TMSs, one at the N-terminus and 12 more together after a hydrophilic domain of about 170 aas, NDG-4.  When the gene is  mutated or deleted, the life span of C. elegans increases up to 5-fold (Brejning et al. 2014).

Animals

NDG-4 of Caenorhabditis elegans

Acyl transferase of 822 aas and 14 putative TMSs.  Has an N-terminal TMS followed bya hydrophilic domain of about 270 aas which may include TMSs, followed by about 13 TMSs.  Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from the intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development (Brejning et al. 2014).  Mutants in the nrf-6 gene have extended lifespans and increased stress resistance (Brejning et al. 2014).

Animals

NRF6 of Caenorhabditis elegans

Putative isovaleryltransferase, MppN of 456aas and 10 putative TMSs.

Bacteria

MppN of Streptomyces hygroscopicus (Q643C2)

Putative O-acetyltransferase, OatA, of 333 aas and 10 TMSs.

Bacteria

OatA of Erwinia amylovora (YP_003531188)

Acyltransferase of 437 aas and 12 TMSs.

AT of Nocardia inohanensis

Membrane protein with acyltransferase 3 domain

Firmicutes

Acyltransferase of Staphylococcus carnosus

Uncharacterized putative acyl transferase of 389 aas and 10 TMSs

UP of Lentisphaera araneosa

Acyltransferase of 329 aas and 10 TMSs.

Acyltransferase of Erwinia sp. Ejp617

Acyltransferase family protein of 648 aas and 11 or 12 TMSs.

Acyltransferase of Rhizorhabdus dicambivorans

1-Acyl-sn-glycerol-3-phosphate acyltransferase gamma, AGPAT3, or Lysophosphatidic acid acyltransferase gamma, of 261 aas and 0 - 2 N-terminal TMSs (Leung 2001).

AGPAT3 of Salmonella enterica subsp. enterica serovar Paratyphi A

The GumF protein of 364 aas and 10 TMSs (Bianco et al. 2014).

Proteobacteria

GumF of Xanthomonas campestris

GumG of 356 aas and 9 or 10 TMSs (Bianco et al. 2014).

Proteobacteria

GumG of Xanthomonas campestris

Uncharacterized protein of 333 aas and 9 TMSs.

UP of Lactobacillus rhamnosus

The succinyl transferase, MdoC, OpgC or YmdD (formerly DUF418), is of 385 aas and 10 TMSs. Osmoregulated periplasmic glucans (OPGs) of E. coli are anionic oligosaccharides that accumulate in the periplasmic space in response to low osmolarity of the medium. Their anionic character is provided by the substitution of the glucosidic backbone by phosphoglycerol originating from  membrane phospholipids and by succinyl residues from an unknown origin. The mdoC gene is within the mdoGH operon necessary for the synthesis of the OPG backbone (Lacroix et al. 1999). The same is true for Rhodobacter spheroides in which in correspondng operon is the opgGIHC operon (Cogez et al. 2002).

MdoC of E. coli

Acyltransferase of 239 aas and 6 TMSs.

Acyltransferase of Leptospira interrogans

MdoC homologue of 366 aas and 10 TMSs.

MdoC of Clostridium uliginosum

OpgC homologue of 351 aas and 10 TMSs in a 3 + 4 + 3 arrangment.

OpgC homolgue of Haemophilus haemolyticus

Uncharacterized acyl transferase of 366 aas and 10 TMSs

UP of Zobellia galactanivorans

Uncharacterized acyl transferase of 336 aas and 10 TMSs.

UP of Staphylococcus aureus

Uncharacterized acyltransferase of 409 aas ahd 10 TMSs

UP of Nocardia flavorosea

Succinyl transferase, OpgC or MdoC (formerly DUF418) of 399 aas and 10 TMSs.  It succinylates the osmotically-induced periplasmic oligoglucan (OPG) and is encoded by a gene downstream of the OPG-encoding genes, (opgGIH) (Cogez et al. 2002).

ObgC of Rhodobacter sphaeroides

OpgC homologue of 397 aas and 10 TMSs in a 3 + 4 + 3 arrangement.

OpgC of Aureimonas altamirensis

OpgC homologue of 353 aas and 10 TMSs in a 3 + 4 + 3 arrangement.

OpgC homolgue of Candidatus Saccharibacteria bacterium

OpgC of 397 aas and 10 TMSs in an apparent 3 + 4 + 3 TMS arrangement.

OpgC of Klebsiella pneumoniae

OpgC homologue of 388 aas and 9 TMSs in a 2 + 4 + 3 arrangement. The N-terminal TMS may be missing because of an incorrect initiation codon assignment.

OpgC of Gordonia phthalatica